Silpa Shirodkar made her debut with the Ramesh Sippy's Bhrashtachar 1989 film with Mithun Chakraborty and Rekha in which she played the role of a blind girl. She starred opposite Anil Kapoor in the hit 1990 film Kishen Kanhaiya. She appeared in several other hit films such as Trinetra (1991), Hum (1991), Khuda Gawah (1992), Aankhen (1993), Pehchaan (1993), Gopi Kishan (1994), Bewafa Sanam (1995) and Mrityudand (1997). Her last film appearance was in the 2000 film Gaja Gamini. She was nominated for the Filmfare Award for Best Supporting Actress for Khuda Gawah.Shilpa paired in 9 films with Mithun Chakraborty and fans appreciated their onscreen pairing.She took a 13-year hiatus from show business to raise her family and in 2013 she made her return to acting, this time on television. She shifted residence to Mumbai and started shooting in the Delhi suburb for her comeback vehicle, Zee TV's new show Ek Mutthi Aasmaan based on the life of domestic helps.The series ended in late 2014. Her second television serial Silsila Pyar Ka started airing on Star Plus on January 4, 2016.