Mrudula started as a child anchor in the program Dial & See telecast in Jeevan TV along with her brother Midhun Murali as co-anchor. She has acted numerous ad-films in Tamil and Malayalam and also shot for a Tamil film, the Ilaiyaraaja musical Kangalum Kavipaduthey in 2007,which did not get a theatrical release. She stepped into the film industry with the Malayalam film Red Chillies. She received critical acclaim for her role as Shenbagavalli in her debut Tamil film Nagaraja Cholan MA, MLA.