Mohan Kupleri made his debut cinema with Grihaprevesam (1992). His films include Nandini Oppol (1994), Kaathil Oru Kinnaram (1996), Dravidan (1998), Kattathoru Penpoovu (1998), Savithriyude Aranjanam (2002), Payum Puli (2007), Evadaina Sare (Telugu language)[2] (2007), Grihanathan (2012) and upcoming movie Chandragiri Junction.He got into the world of cinema by assisting noted director Adoor Gopalakrishnan. He worked with Adoor Gopalakrishnan movies like Elippathayam, Mukhamukham, Anantaram etc. which won lot of national and international awards.