Lakshmi Manchu is the only daughter of actor Mohan Babu and Vidya Devi. She has two younger brothers, Vishnu Manchu and Manoj Manchu. Having started her career at the age of 4, Manchu has been in 20 feature films in India and the U.S. She co-owns Sree Lakshmi Prasanna Pictures, a production company that has produced fifty-six feature films to date. In December 2011, she was signed on to portray a role in Mani Ratnam's Tamil film Kadal after a successful audition.