Keerthi Reddy has acted in Hindi, Tamil, Telugu and  Kannada movies. In 1996, Keerthi Reddy made her first film debut in a comedy thriller GunShot, opposite Ali directed by S V Krishna Reddy . In 1998 Reddy portrayed a role in Tholi Prema opposite Telugu Powerstar Pawan Kalyan which is a classical love story in Telugu Film industry. In 2000, Reddy made her Bollywood debut in Tera Jadoo Gayaa opposite Abhishek Bachchan. Her next film Pyaar Ishq Aur Mohabbat featured her as Isha Nair opposite the debutant Arjun Rampal. Her role was of a girl who was loved by three men Gaurav Saxena, Yash Sabarwal and Taj Bharadwaj. The latter two roles were portrayed by Sunil Shetty and Aftab Shivdasani. In 2002, Reddy had a supporting role in Badhaai Ho Badhaai. Gunshot, Super Star, Arjun, Nandhini, Jolly etc .are her popular films.